Born in Caldwell, New Jersey, on March 8, 1961, as Debra Frances Manheim, Manheim grew up in Peoria, Illinois, under the care of her parents, Sylvia, a teacher, and Jerome Manheim, a mathematics professor.
She is of Jewish descent, and has a brother named Karl, who would become a law professor at Loyola Law School.
In 1999, she was awarded the Women in Film Lucy Award.
Currently, Manheim has been involved with the Los Angeles-based charity, Bet Tzedek Legal Services - The House of Justice, in which she serves as a co-chairwoman for their annual fundraiser, The Justice Ball.
She has a son whom she named Milo, who was born on March 6, 2001.
" She later followed up on this exclamation with a one-woman show titled Wake Up, I'm Fat!
, which was then followed by her autobiography with the same name.
Manheim worked as a sign-language interpreter at hospitals (a skill which would later be used on The Practice, in an episode of Law & Order, and in the movie Mercury Rising).
In 1983, she made a brief appearance as a girl in an elevator in Sudden Impact.
Other television credits of hers include Chicago Hope, Ally Mc Beal, Will & Grace, Boston Public, Two and a Half Men, The L Word, How I Met Your Mother, Hannah Montana, and Criminal Minds.
In addition, Manheim has several film credits, including Romy and Michele's High School Reunion, Happiness (which went on to earn her and her costars a National Board of Review Award for Best Acting by an Ensemble), The Laramie Project, Scary Movie 3, Dark Water, and An Unfinished Life.
Actress Camryn Manheim has a huge regret that's she's not a lesbian.