Sedating antihistamines and

[see Warnings and Precautions (5.5)] Adults and Adolescents 12 years of age and older: 7.5 m L to 20 m L (6 to 16 mg) every 12 hours Children 2 to 11 years of age (approximately 0.2 to 0.4 mg/kg/day): 2 to 3 years: 3.75 m L to 5 m L (3 to 4 mg) every 12 hours 4 to 5 years: 3.75 m L to 10 m L (3 to 8 mg) every 12 hours 6 to 11 years: 7.5 m L to 15 m L (6 to 12 mg) every 12 hours HOW SUPPLIED: Extended-release oral suspension containing 4 mg carbinoxamine maleate per 5 m L Adult (usual): 4 mg po every 4 to 6 hrs; maximum dose: 24 mg/day.

Results of a radiolabeled tissue distribution study in rats and a radioligand H1-receptor binding study in guinea pigs showed that desloratadine did not readily cross the blood brain barrier. Dosing: Oral: Children: 6-11 months: 1 mg once daily 12 months to 5 years: 1.25 mg once daily 6-11 years: 2.5 mg once daily Children /= 12 years and Adults: 5 mg once daily Supplied Syrup (Clarinex®): 0.5 mg/m L (480 m L) [bubble gum flavor] Tablet (Clarinex®): 5 mg Tablet, orally-disintegrating (Clarinex® Redi Tabs®): 5 mg [contains phenylalanine 1.75 mg/tablet] Adult (usual) Chronic idiopathic urticaria: 60 mg orally twice daily.

Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.

Chewable: 2 mg EExtended Release tab: 8 mg, 12 mg, 16 mg Tavist 12 Hour Allergy Tablets: Clemastine fumarate, USP 1.34 mg (equivalent to 1 mg clemastine).

Adults and children 12 years of age and older: take 1 tablet every 12 hours, not more than 2 tablets in 24 hours unless directed by a doctor.

A dose of 60 mg once daily is recommended as the starting dose in patients with decreased renal function Mechanism of Action Fexofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective peripheral H1-receptor antagonist activity.

Both enantiomers of fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects.

Antihistamines are a group of medicines which act by blocking the action of the chemical called histamine in the body.

Either H1 or H2 histamine receptors can be blocked by medicines, but the group commonly known as antihistamines blocks the H1 receptor.

In laboratory animals, no anticholinergic or alpha1-adrenergic blocking effects were observed.

Moreover, no sedative or other central nervous system effects were observed.

Dosage - Oral: Children: Allergic conditions: 0.25 mg/kg/day or 8 mg/m 2 /day in 2-3 divided doses or 2-6 years: 2 mg every 8-12 hours (not to exceed 12 mg/day) 7-14 years: 4 mg every 8-12 hours (not to exceed 16 mg/day) Migraine headaches: 4 mg 2-3 times/day Children /= 12 years and Adults: Spasticity associated with spinal cord damage: 4 mg at bedtime; increase by a 4 mg dose every 3-4 days; average daily dose: 16 mg in divided doses; not to exceed 36 mg/day Children 13 years and Adults: Appetite stimulation (anorexia nervosa): 2 mg 4 times/day; may be increased gradually over a 3-week period to 8 mg 4 times/day Adults: Allergic conditions: 4-20 mg/day divided every 8 hours (not to exceed 0.5 mg/kg/day) Cluster headaches: 4 mg 4 times/day Migraine headaches: 4-8 mg 3 times/day Supplied Syrup, as hydrochloride: 2 mg/5 m L (473 m L) [contains alcohol 5%; mint flavor] Tablet, as hydrochloride: 4 mg Dosage - Oral: Children: 2-5 years: 12.5-25 mg every 6-8 hours, maximum: 75 mg/day 6-12 years: 25-50 mg every 6-8 hours, maximum: 150 mg/day Adults: 50-100 mg every 4-6 hours, not to exceed 400 mg/day Supplied Caplet (Trip Tone®): 50 mg Tablet (Dramamine®): 50 mg Tablet, chewable (Dramamine®): 50 mg [contains phenylalanine 1.5 mg/tablet and tartrazine; orange flavor] Mechanism of Action Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects.

Comments are closed.