Buspirone has moderate affinity for brain D2-dopamine receptors.
Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.
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Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects.
It also lacks the prominent sedative effect that is associated with more typical anxiolytics.
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Concurrent use with strong CYP3A4 inhibitor: 1 mg before bedtime; if needed, dose may be increased to 2 mg. Our patient's renal function remained stable throughout the hospital course, which caused us to look further for an explanation for the propylene glycol-induced lactic acidosis.
Dosage adjustment in hepatic impairment: Mild-to-moderate: Use with caution; dosage adjustment unnecessary Severe: Maximum dose: 2 mg Supplied: 1 mg, 2 mg, 3 mg tablet. Based on the Naranjo probability scale, propylene glycol was determined to be the probable cause of lactic acidosis.Large doses of liquid lorazepam (i.e., 60 mg of 2 mg/m L every six hours) may lead to diarrhea because of the high PEG and PG content. SUPPLIED: Capsule: 10 mg, 15 mg, 30 mg Tablet: 15 mg INDICATIONS AND USAGE Restoril™ (temazepam) is indicated for the short-term treatment of insomnia (generally 7 to 10 days).Intubated patients (Continuous infusion): 1 to 7 mg/hr. M.: 0.07-0.08 mg/kg 30-60 minutes prior to surgery/procedure; usual dose: 5 mg; Note: Reduce dose in patients with COPD, high-risk patients, patients /= 60 years of age, and patients receiving other narcotics or CNS depressants I. over at least 2 minutes; slowly titrate to effect by repeating doses every 2-3 minutes if needed; usual total dose: 2.5-5 mg; use decreased doses in elderly. Maintenance: 25% of dose used to reach sedative effect. V.: Induction: Unpremedicated patients: 0.3-0.35 mg/kg (up to 0.6 mg/kg in resistant cases) Premedicated patients: 0.15 to 0.35 mg/kg. continuous infusion: 100 mg in 250 m L D5W or NS (if patient is fluid-restricted, may concentrate up to a maximum of 0.5 mg/m L); initial dose: 0.02-0.08 mg/kg (~1 mg to 5 mg in 70 kg adult) initially and either repeated at 5-15 minute intervals until adequate sedation is achieved or continuous infusion rates of 0.04-0.2 mg/kg/hour and titrate to reach desired level of sedation. If additional titration is needed, give no more than 1 mg over 2 minutes, waiting another 2 or more minutes to evaluate sedative effect. For patients with short-term insomnia, instructions in the prescription should indicate that Restoril™ (temazepam) should be used for short periods of time (7 to 10 days).Avoid abrupt discontinuation - requires gradual reduction in dose.Dosing adjustment in renal or hepatic impairment: Buspirone is metabolized by the liver and excreted by the kidneys.---- The lorazepam solvents polyethylene glycol (PEG) and propylene glycol (PG) have been implicated as the cause of reversible acute tubular necrosis, lactic acidosis, and hyperosmolar states after prolonged high-dose infusions. Dosing (Adults): Anxiety: 10-30 mg 3-4 times/day Ethanol withdrawal: 15-30 mg 3-4 times/day Hypnotic: 15-30 mg Elderly: Oral: Anxiety: 10 mg 2-3 times/day; increase gradually as needed to a total of 30-45 mg/day.